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I rinse mine out several times a day, but I do brush them with my toothbrush after I brush my teeth. I brush the inside and out. You can drink water, just not suppose to eat or drink beverages with them on. Im not sure about the smoking, it seems if you smoked with them in, the smoke would get on the trays, then you would have to clean them more often, but the smoke wouldnt get on your teeth would it? I also used some peroxide and water to clean them out before bed. Im not for sure that it matters how you clean them as long as you get them clean without damaging them, toothpaste, toothbrush, polishers, water, ect. The tooth brush hasnt damaged mine at all.
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