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Well what happens is when you first put in a new tray you will experience pressure because the tray pushes the teeth into their new position, well almost. After a few days the teeth are in the new position of the tray, so there is no more discomfort. The reason you have to leave the trays in for 2 weeks is to allow the bone in your jaw to heal. When you take it out, you interupt the healing process and the teeth naturally migrate back to where they were. This is why you can't leave them out for a long time as all the work can disapear if you leave them out for too long.
Those who change their trays before 2 weeks are risking long term health issues. Of course everyone is different, but this is just standard human anatomy.
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