I experienced coughing at the beginning of the first set; also sore throat, chapped lips and dry mouth.
I did some research and gathered that it was likely caused by the chemical residue from the post-production sterilization process. Some people are more sensitive to the chemical than others. Most patients experience dry mouth and chapped lips and the problems usually go away after a few days of wearing a new set.
The problems went away for me on the 3rd day after I soaked the aligners in denture cleanser for an hour and thoroughly clean them with a soft toothbrush before wearing them again. I have done this with every new set and haven’t had any problems since (I’m on the 6th set now).
Some denture cleanser and mouthwash could also cause sore throat and coughing for some people. I try to avoid the strong ones.
Good luck!


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